Hydroxypropyl methylcellulose (HPMC) ndi polima yopanga semi-synthetic yomwe imagwiritsidwa ntchito kwambiri m'mafakitale ambiri, makamaka m'munda wamankhwala. HPMC wakhala excipient yofunika kwambiri mu kukonzekera mankhwala chifukwa biocompatibility, sanali kawopsedwe ndi kwambiri thupi ndi mankhwala katundu.
(1) Makhalidwe oyambira a kalasi yamankhwala HPMC
HPMC ndi non-ionic mapadi efa wokonzedwa ndi zimene mapadi ndi propylene okusayidi ndi methyl kolorayidi pansi zinthu zamchere. Kapangidwe kake kapadera ka mankhwala kumapatsa HPMC kusungunuka kwabwino kwambiri, kukhuthala, kupanga filimu ndi emulsifying katundu. Zotsatirazi ndi zina mwazofunikira za HPMC:
Kusungunuka kwamadzi ndi kudalira pH: HPMC imasungunuka m'madzi ozizira ndikupanga yankho lowonekera. Kukhuthala kwa yankho lake kumakhudzana ndi ndende komanso kulemera kwa maselo, ndipo imakhala ndi kukhazikika kwa pH ndipo imatha kukhala yokhazikika m'malo a acidic ndi amchere.
Thermogel katundu: HPMC amaonetsa wapadera thermogel katundu akatenthedwa. Ikhoza kupanga gel osakaniza ikatenthedwa kutentha kwina ndikubwerera kumadzimadzi pambuyo pozizira. Katunduyu ndi wofunikira kwambiri pokonzekera kumasulidwa kwamankhwala kosalekeza.
Biocompatibility and non-toxicity: Popeza HPMC ndi yochokera ku cellulose ndipo ilibe ndalama ndipo sichingafanane ndi zosakaniza zina, ili ndi biocompatibility yabwino kwambiri ndipo sidzalowetsedwa m'thupi. Ndiwopanda poizoni.
(2) Kugwiritsa ntchito HPMC pamankhwala
HPMC imagwiritsidwa ntchito kwambiri m'makampani opanga mankhwala, kutengera magawo angapo monga mankhwala apakamwa, apakhungu ndi obaya. Malangizo ake akuluakulu ndi awa:
1. Zinthu zopangira mafilimu m'mapiritsi
HPMC chimagwiritsidwa ntchito ❖ kuyanika ndondomeko ya mapiritsi monga filimu kupanga zakuthupi. Piritsi ❖ kuyanika sangathe kuteteza mankhwala ku chikoka cha kunja chilengedwe, monga chinyezi ndi kuwala, komanso kubisa fungo loipa ndi kukoma kwa mankhwala, potero kuwongolera kutsatira kwa odwala. Kanema wopangidwa ndi HPMC ali ndi kukana madzi abwino komanso mphamvu, zomwe zimatha kuwonjezera moyo wa alumali wamankhwala.
Panthawi imodzimodziyo, HPMC ingagwiritsidwenso ntchito ngati chigawo chachikulu cha ma nembanemba omwe amawongolera kuti apange mapiritsi otulutsidwa ndi olamulidwa. Matenthedwe ake a gel osakaniza amalola kuti mankhwala atulutsidwe m'thupi pamlingo wodziwikiratu, potero amakwaniritsa zotsatira za chithandizo chamankhwala chokhalitsa. Izi ndizofunikira kwambiri pochiza matenda osachiritsika, monga zosoweka zanthawi yayitali za odwala omwe ali ndi matenda a shuga ndi matenda oopsa.
2. Monga wothandizira-kumasulidwa kosalekeza
HPMC chimagwiritsidwa ntchito ngati kupitiriza-kumasulidwa wothandizira pakamwa mankhwala kukonzekera. Chifukwa amatha kupanga gel osakaniza m'madzi ndipo gel osanjikiza pang'onopang'ono amasungunuka pamene mankhwala amatulutsidwa, amatha kuyendetsa bwino mlingo wa kutulutsidwa kwa mankhwala. Izi ndizofunikira makamaka pamankhwala omwe amafunikira kutulutsidwa kwamankhwala kwanthawi yayitali, monga insulin, antidepressants, etc.
M'matumbo am'mimba, gel wosanjikiza wa HPMC amatha kuwongolera kuchuluka kwa mankhwalawa, kupewa kutulutsa kwachangu kwa mankhwalawa munthawi yochepa, potero kuchepetsa zotsatira zoyipa ndikutalikitsa mphamvu. Katundu wokhazikikayu ndi woyenera kwambiri pochiza mankhwala omwe amafunikira kukhazikika kwamankhwala amagazi, monga maantibayotiki, mankhwala oletsa khunyu, etc.
3. Monga chomangira
HPMC nthawi zambiri imagwiritsidwa ntchito ngati binder popanga mapiritsi. Powonjezera HPMC ku mankhwala particles kapena ufa, fluidity ake ndi adhesion akhoza bwino, potero kusintha psinjika zotsatira ndi mphamvu piritsi. Kusakhala kwa kawopsedwe komanso kukhazikika kwa HPMC kumapangitsa kuti ikhale yomangira yabwino m'mapiritsi, ma granules ndi makapisozi.
4. Monga thickener ndi stabilizer
Pokonzekera zamadzimadzi, HPMC imagwiritsidwa ntchito kwambiri ngati thickener ndi stabilizer mu zakumwa zosiyanasiyana zam'kamwa, madontho am'maso ndi zopaka pamutu. Kukhuthala kwake kumatha kukulitsa kukhuthala kwa mankhwala amadzimadzi, kupewa stratification kapena mvula, ndikuwonetsetsa kugawa kofanana kwa mankhwala. Panthawi imodzimodziyo, mafuta odzola ndi osungunuka a HPMC amathandizira kuchepetsa kupweteka kwa maso m'madontho a maso ndikuteteza maso ku mkwiyo wakunja.
5. Ntchito makapisozi
Monga cellulose yochokera ku chomera, HPMC ili ndi biocompatibility yabwino, ndikupangitsa kuti ikhale yofunika kwambiri popanga makapisozi a zomera. Poyerekeza ndi makapisozi amtundu wa gelatin wanyama, makapisozi a HPMC amakhala okhazikika bwino, makamaka m'malo otentha kwambiri komanso chinyezi chambiri, ndipo sizosavuta kupunduka kapena kusungunuka. Komanso, HPMC makapisozi ndi oyenera zamasamba ndi odwala amene matupi awo sagwirizana gelatin, kukulitsa kukula kwa ntchito kapisozi mankhwala.
(3) Kugwiritsa ntchito mankhwala ena a HPMC
Kuphatikiza pakugwiritsa ntchito mankhwala omwe ali pamwambapa, HPMC itha kugwiritsidwanso ntchito m'malo enaake amankhwala. Mwachitsanzo, pambuyo pa opaleshoni ya ophthalmic, HPMC imagwiritsidwa ntchito m'madontho a diso ngati mafuta kuti achepetse kukangana pamwamba pa diso ndikulimbikitsa kuchira. Kuphatikiza apo, HPMC itha kugwiritsidwanso ntchito muzodzola ndi ma gels kulimbikitsa kuyamwa kwamankhwala ndikuwongolera mphamvu yamankhwala am'deralo.
Pharmaceutical grade HPMC imagwira ntchito yofunika kwambiri pokonzekera mankhwala chifukwa cha thupi ndi mankhwala. Monga multifunctional mankhwala excipient, HPMC akhoza kusintha bata la mankhwala ndi kulamulira amasulidwe mankhwala, komanso kusintha zinachitikira mankhwala ndi kuonjezera kutsatira kwa odwala. Ndi kupita patsogolo kosalekeza kwa ukadaulo wamankhwala, gawo logwiritsira ntchito la HPMC likhala lokulirapo ndipo litenga gawo lofunikira kwambiri pakupanga mankhwala amtsogolo.
Nthawi yotumiza: Sep-19-2024