Hydroxylopyolin (HPMC) ndi polima wogwiritsidwa ntchito kwambiri m'makampani opanga mankhwala ndipo ndi njira yofunika kwambiri. Amagwiritsidwa ntchito ngati zomatira mumlingo wolimba (monga mapiritsi, makapisozi, ndi tinthu tating'onoting'ono), mamasukidwe akayendedwe owonjezera komanso kuwonongeka.
Pokonzekera mankhwala, kusungunuka kwa zosakaniza zogwira ntchito n'kofunika kuyamwa ndi kupanga zotsatira za mankhwala. Komabe, kusungunuka kwa zinthu zogwira ntchito kungalepheretsedwe ndi ndondomekoyi. Choncho, ndikofunika kumvetsetsa khalidwe losungunuka la HPMC mu ndondomeko ya mankhwala chifukwa zimakhudza momwe mtundu wa mlingo umayendera.
Njira yothetsera HPMC
US Pharmacy (USP) yakhazikitsa njira yoyesera yosungunulira HPMC. Njira imeneyi nthawi zambiri imaphatikizapo kugwiritsa ntchito zida zosungunulira, zomwe zimafanizira ndikuyesa kusungunuka kwa mtundu wa mlingo mu sing'anga ya yankho. Kuyezetsa kumaphatikizapo kuyika mlingo mudengu kapena papala, ndipo dengu kapena paddle imazungulira mu chidebe chomwe chili ndi sing'anga yosungunuka.
Sing'anga yosungunuka iyenera kusankhidwa molingana ndi momwe akuyembekezeka kugwiritsa ntchito mlingo (monga kusungunuka kwa m'mimba kapena m'mimba). Sing'anga yosungunuka ya HPMC imaphatikizapo madzi, phosphate buffer solution ndi simulation gastric juice (SGF) kapena analogi intestinal fluid (SIF).
Kuti zitsimikizire kubwerezabwereza komanso kulondola, magawo oyesa ayenera kukhala okhazikika, monga kuthamanga kwa kasinthasintha, kutentha, ndi kusungunula voliyumu yapakati ndi nthawi yachitsanzo. Kenako gwiritsani ntchito njira yoyenera yowunikira kuti mufufuze yankho lachitsanzo lomwe limapezedwa ndi nthawi zosiyanasiyana kuti mudziwe kuchuluka kwa kusungunuka kwa HPMC.
Njira zodzitetezera Pochita mayeso a HPMC kuthetsa
1. Kusankhidwa kwa sing'anga yoyenera yosungunulira: Kusankhidwa kwa sing'anga yosungunulira kumatengera momwe akuyembekezeka kugwiritsa ntchito fomu ya mlingo. Kusankha njira yoyenera yosungunulira ndiyofunikira kwambiri chifukwa idzakhudza kutha kwa HPMC.
2. Kutsimikizira molondola njira ya solubility: Kutsimikizira njira ya solubility kuti iwonetsetse kuti ndi yoyenera ndipo ndikofunika kukwaniritsa zofunikira za bungwe loyang'anira. Kutsimikizira kuyenera kuphatikizira kulimba ndi kubwereza kwa muyeso.
3. Kuyimitsidwa kwa magawo oyesa: Zoyeserera, monga liwiro lozungulira, kutentha, ndi voliyumu yapakatikati yosungunuka zimakhudza zotsatira za mayeso osungunuka. Chifukwa chake, magawowa ayenera kukhala okhazikika kuti awonetsetse kuti akuwonekeranso komanso kusanthula kolondola.
4. Zitsanzo: Kuyesa mosamala ndikofunikira kuti mupeze zitsanzo zoyimira kuchokera ku sing'anga yosungunuka. Samalani nthawi ndi zitsanzo kuti muwonetsetse kuti chitsanzocho chikusonkhanitsidwa nthawi imodzi.
5. Njira yowunikira: Sankhani njira yowunikira yowunikira idzatsimikiziridwa, ndipo iyenera kukhala ndi chidziwitso choyenera, kusankha ndi kulondola.
Mwachidule, kuyezetsa kwa HPMC ndi chida chofunikira pakukula kwa mankhwala ndi chilinganizo cha mankhwala. Laboratory yoyang'anira khalidwe imachitika nthawi zonse kuti iwonetsetse kumasulidwa kolondola kwa zosakaniza zogwira ntchito, ndipo mankhwalawa ndi otetezeka komanso ogwira mtima. Kulakwitsa mu njira yoyenera yoyesera kungayambitse kusamvana ndi kunena zabodza pa mphamvu ya mankhwala. Choncho, ndikofunika kutsatira miyezo ndi njira zodzitetezera panthawi ya mayesero a kusungunuka.
Nthawi yotumiza: Jun-29-2023