HPMC (hydroxypropyl methylcellulose) ndi thickener ndi stabilizer ambiri ntchito pomanga zipangizo, zokutira, mankhwala ndi zakudya. HPMC 15 cps zikutanthauza kuti mamasukidwe akayendedwe ake ndi 15 centipoise, amene ndi otsika mamasukidwe akayendedwe kalasi.
1. Wonjezerani HPMC ndende
The kwambiri mwachindunji ndi zothandiza njira kuonjezera mamasukidwe akayendedwe a HPMC ndi kuonjezera ndende yake mu yankho. Pamene gawo lalikulu la HPMC likuwonjezeka, kukhuthala kwa yankho kudzawonjezekanso. Pachimake njira imeneyi kuti HPMC kumawonjezera mamasukidwe akayendedwe a yankho mwa kupanga atatu azithunzithunzi maukonde dongosolo. Pamene chiwerengero cha mamolekyu a HPMC mu yankho chikuwonjezeka, kachulukidwe ndi mphamvu ya dongosolo la maukonde adzawonjezeka, potero kuonjezera mamasukidwe akayendedwe a yankho. Komabe, pali malire kuonjezera ndende. Kuchulukirachulukira kwa HPMC kumapangitsa kuti yankho lichepe, ndipo zitha kukhudzanso magwiridwe ake pazinthu zina, monga zomangamanga ndi magwiridwe antchito.
2. Sungani kutentha kwa yankho
Kutentha kumakhudza kwambiri kusungunuka ndi kukhuthala kwa HPMC. Pa kutentha otsika, mamasukidwe akayendedwe a HPMC njira ndi apamwamba; pamene kutentha kwambiri, kukhuthala kwa HPMC yankho kudzachepa. Choncho, kuchepetsa kutentha kwa yankho moyenera panthawi yogwiritsira ntchito kumatha kuonjezera kukhuthala kwa HPMC. Kuyenera kudziŵika kuti solubility wa HPMC mu yankho ndi osiyana pa kutentha osiyana. Nthawi zambiri zimakhala zosavuta kumwazikana m'madzi ozizira, koma zimatengera nthawi kuti zisungunuke. Imasungunuka mofulumira m'madzi ofunda, koma kukhuthala kwake kumakhala kochepa.
3. Sinthani pH mtengo wa zosungunulira
Kukhuthala kwa HPMC kumakhudzidwanso ndi pH ya yankho. Pansi pazandale kapena pafupi ndi ndale, kukhuthala kwa yankho la HPMC ndikokwera kwambiri. Ngati pH mtengo wa yankho ukupatuka ku ndale, kukhuthala kungachepe. Chifukwa chake, kukhuthala kwa yankho la HPMC kumatha kukulitsidwa mwakusintha moyenera pH ya yankho (mwachitsanzo, powonjezera buffer kapena acid-base regulator). Komabe, pakugwira ntchito kwenikweni, kusintha kwa pH kuyenera kukhala kosamala kwambiri, chifukwa kusintha kwakukulu kungayambitse kuwonongeka kwa HPMC kapena kuwonongeka kwa ntchito.
4. Sankhani chosungunulira choyenera
The solubility ndi mamasukidwe akayendedwe a HPMC osiyana zosungunulira kachitidwe osiyana. Ngakhale HPMC makamaka ntchito njira amadzimadzi, Kuwonjezera ena solvents organic (monga Mowa, isopropanol, etc.) kapena mchere osiyana akhoza kusintha unyolo conformation wa molekyulu HPMC, potero zimakhudza mamasukidwe akayendedwe. Mwachitsanzo, pang'ono zosungunulira organic akhoza kuchepetsa kusokoneza mamolekyu madzi pa HPMC, potero kuwonjezera mamasukidwe akayendedwe a yankho. Muzochita zenizeni, ndikofunikira kusankha zosungunulira organic zoyenera malinga ndi momwe zimagwiritsidwira ntchito.
5. Gwiritsani ntchito zowonjezera zowonjezera
Nthawi zina, zina zowonjezera zothandizira zitha kuwonjezeredwa ku HPMC kuti zitheke kukulitsa kukhuthala. Zomwe zimagwiritsidwa ntchito nthawi zambiri zimakhala ngati xanthan chingamu, guar chingamu, carbomer, ndi zina zotero. Zowonjezerazi zimagwirizana ndi mamolekyu a HPMC kuti apange gel osakaniza kapena mawonekedwe a maukonde, kuonjezera kukhuthala kwa yankho. Mwachitsanzo, xanthan chingamu ndi polysaccharide yachilengedwe yokhala ndi mphamvu yakukhuthala. Akagwiritsidwa ntchito ndi HPMC, awiriwa amatha kupanga synergistic kwenikweni ndikuwonjezera kukhuthala kwa dongosolo.
6. Sinthani kuchuluka kwa kusintha kwa HPMC
Kukhuthala kwa HPMC kumakhudzananso ndi kuchuluka kwa m'malo mwa magulu ake a methoxy ndi hydroxypropoxy. Mlingo wa m'malo umakhudza kusungunuka kwake ndi kukhuthala kwa yankho. Posankha HPMC ndi madigiri osiyanasiyana olowa m'malo, kukhuthala kwa yankho kumatha kusinthidwa. Ngati kukhuthala kwapamwamba kwa HPMC kumafunika, chinthu chokhala ndi methoxy yapamwamba chikhoza kusankhidwa, chifukwa chapamwamba kwambiri cha methoxy, mphamvu ya hydrophobicity ya HPMC, ndi mamasukidwe akayendedwe pambuyo pa kusungunuka ndipamwamba kwambiri.
7. Wonjezerani nthawi yowonongeka
Nthawi yomwe HPMC imasungunuka idzakhudzanso kukhuthala kwake. Ngati HPMC si kwathunthu kusungunuka, ndi mamasukidwe akayendedwe a yankho sangafikire boma abwino. Choncho, moyenerera kuwonjezera nthawi kuvunda kwa HPMC m'madzi kuonetsetsa kuti HPMC kwathunthu hydrated angathe kuonjezera mamasukidwe akayendedwe a yankho lake. Makamaka pamene kusungunula pa kutentha kotsika, kusungunuka kwa HPMC kungakhale kochedwa, ndipo kukulitsa nthawi ndikofunikira.
8. Sinthani mikhalidwe yometa ubweya
Kukhuthala kwa HPMC kumagwirizananso ndi mphamvu yakumeta ubweya yomwe imayikidwa pakugwiritsa ntchito. Pansi pamikhalidwe yometa ubweya wambiri, kukhuthala kwa yankho la HPMC kudzachepa kwakanthawi, koma kukameta ubweya kukasiya, kukhuthala kudzachira. Kwa njira zomwe zimafuna kuwonjezereka kwa viscosity, mphamvu ya kumeta ubweya yomwe yankho limakhalapo likhoza kuchepetsedwa, kapena lingagwiritsidwe ntchito pansi pa mikhalidwe yotsika kwambiri kuti likhale ndi kukhuthala kwapamwamba.
9. Sankhani kulemera kwa maselo oyenera
The molekyulu kulemera kwa HPMC mwachindunji amakhudza mamasukidwe akayendedwe ake. HPMC yokhala ndi kulemera kwakukulu kwa maselo imapanga dongosolo lalikulu la maukonde mu yankho, zomwe zimapangitsa kukhuthala kwapamwamba. Ngati mukufuna kuonjezera mamasukidwe akayendedwe a HPMC, mukhoza kusankha HPMC mankhwala ndi apamwamba maselo kulemera. Ngakhale HPMC 15 cps ndi chinthu chotsika kukhuthala, kukhuthala kumatha kuonjezedwa posankha chosiyana cholemera kwambiri chazinthu zomwezo.
10. Ganizirani zinthu zachilengedwe
Zinthu zachilengedwe monga chinyezi ndi kupanikizika zimathanso kukhala ndi vuto linalake la kukhuthala kwa yankho la HPMC. Pamalo a chinyezi chambiri, HPMC imatha kuyamwa chinyezi kuchokera mumlengalenga, zomwe zimapangitsa kuti kukhuthala kwake kuchepe. Pofuna kupewa izi, malo opangira kapena kugwiritsa ntchito malo amatha kuyendetsedwa bwino kuti chilengedwe chisamawume komanso kuti chikhale chovuta kuti chisungitse kukhuthala kwa yankho la HPMC.
Pali njira zambiri kuonjezera mamasukidwe akayendedwe a HPMC 15 cps njira, kuphatikizapo kuwonjezeka ndende, kulamulira kutentha, kusintha pH, ntchito thickening zothandizira, kusankha mlingo woyenera m'malo ndi maselo kulemera, etc. Njira yeniyeni kusankhidwa zimadalira kwenikweni ntchito. zochitika ndi ndondomeko zofunika. Pogwira ntchito zenizeni, nthawi zambiri pamafunika kuganizira mozama zinthu zingapo ndikupanga kusintha koyenera komanso kukhathamiritsa kuti muwonetsetse kuti yankho la HPMC likuyenda bwino pamapulogalamu enaake.
Nthawi yotumiza: Oct-16-2024