Hydroxypropyl methylcellulose (HPMC), monga chochokera ku cellulose wamba, amagwiritsidwa ntchito kwambiri pomanga, mankhwala, chakudya, mankhwala a tsiku ndi tsiku ndi mafakitale ena. Ubwino wa HPMC umayesedwa makamaka kuchokera kuzinthu zakuthupi ndi zamankhwala, magwiridwe antchito komanso magwiridwe antchito.
1. Maonekedwe ndi mtundu
HPMC nthawi zambiri imakhala yoyera kapena yopanda-yoyera ufa kapena ma granules. Ngati pali kusintha kwakukulu kwa mtundu, monga chikasu, imvi, ndi zina zotero, zingatanthauze kuti chiyero chake sichili chapamwamba kapena choipitsidwa. Kuphatikiza apo, kufanana kwa tinthu tating'onoting'ono kumawonetsanso kuwongolera kwa njira yopangira. Good HPMC particles ayenera wogawana anagawira popanda agglomeration zoonekeratu kapena zosafunika.
2. Kuyezetsa kusungunuka
HPMC ali wabwino kusungunuka madzi, amene ndi chizindikiro chofunika kuweruza khalidwe lake. Kupyolera mu kuyesa kosavuta kwa kusungunuka, kusungunuka kwake ndi kukhuthala kwake kungayesedwe. Njira zake ndi izi:
Tengani pang'ono HPMC ufa, pang'onopang'ono kuwonjezera madzi ozizira kapena firiji madzi m'chipinda, ndi kuona Kutha kwake. HPMC yapamwamba iyenera kumwazikana molingana pakanthawi kochepa popanda mvula yowoneka bwino, ndipo pomaliza pake ipange njira yowonekera kapena yosokoneza pang'ono.
Kuwonongeka kwa HPMC kumakhudzana ndi kapangidwe kake ka maselo, kuchuluka kwa m'malo, komanso kuyeretsa kwadongosolo. HPMC yosakhala bwino imatha kusungunuka pang'onopang'ono komanso mosavuta kupanga magazi omwe ndi ovuta kuwola.
3. Muyezo wa viscosity
Viscosity ndi imodzi mwazinthu zofunika kwambiri pamtundu wa HPMC. Kukhuthala kwake m'madzi kumakhudzidwa ndi kulemera kwa maselo ndi kuchuluka kwa kulowetsedwa, ndipo nthawi zambiri amayezedwa ndi viscometer yozungulira kapena capillary viscometer. Njira yeniyeni ndiyo kusungunula kuchuluka kwa HPMC m'madzi, kukonzekera njira yothetsera vuto linalake, ndiyeno kuyeza kukhuthala kwa yankho. Malingana ndi deta ya viscosity, zikhoza kuweruzidwa kuti:
Ngati mtengo wa viscosity uli wotsika kwambiri, ukhoza kutanthauza kuti kulemera kwa maselo ndi kochepa kapena kwawonongeka panthawi yopanga;
Ngati mtengo wa viscosity ndi wokwera kwambiri, ukhoza kutanthauza kuti kulemera kwa maselo ndi kwakukulu kwambiri kapena m'malo mwake ndi wosiyana.
4. Kuzindikira chiyero
Kuyera kwa HPMC kukhudza mwachindunji magwiridwe ake. Zogulitsa zokhala ndi chiyero chochepa nthawi zambiri zimakhala ndi zotsalira zambiri kapena zonyansa. Chigamulo choyambirira chikhoza kupangidwa ndi njira zosavuta izi:
Mayeso otsalira pakuwotcha: Ikani chitsanzo chochepa cha HPMC mu ng'anjo yotentha kwambiri ndikuwotcha. Kuchuluka kwa zotsalira kungasonyeze zili mu mchere mchere ndi ayoni zitsulo. Zotsalira za HPMC zapamwamba ziyenera kukhala zazing'ono kwambiri.
Kuyesa kwa pH: Tengani kuchuluka koyenera kwa HPMC ndikusungunula m'madzi, ndipo gwiritsani ntchito pepala loyesa pH kapena mita ya pH kuti muyese kufunikira kwa pH ya yankho. Nthawi zonse, yankho lamadzi la HPMC liyenera kukhala pafupi ndi ndale. Ngati ndi acidic kapena zamchere, zonyansa kapena zopangidwa ndi zinthu zitha kukhalapo.
5. Thermal katundu ndi kutentha bata
Powotcha chitsanzo cha HPMC, kukhazikika kwake kwamafuta kumatha kuwonedwa. HPMC yapamwamba kwambiri iyenera kukhala ndi kukhazikika kwamafuta panthawi yotentha ndipo sayenera kuwola kapena kulephera mwachangu. Njira zoyesera zoyeserera zamafuta akuphatikiza:
Kutenthetsa pang'ono chitsanzo pa mbale yotentha ndikuwona malo ake osungunuka ndi kutentha kwake.
Ngati chitsanzocho chikuyamba kuwola kapena kusintha mtundu pa kutentha kochepa, zikutanthauza kuti kutentha kwake kumakhala kosauka.
6. Kutsimikiza kwa chinyezi
Chinyezi chochuluka kwambiri cha HPMC chidzasokoneza kukhazikika kwake kosungirako ndi magwiridwe ake. Chinyezi chake chingadziwike ndi njira yolemetsa:
Ikani chitsanzo cha HPMC mu uvuni ndikuwumitsa pa 105 ℃ mpaka kulemera kosalekeza, kenaka muwerenge kusiyana kwa kulemera kwake musanayambe kapena kuyanika kuti mupeze chinyezi. HPMC yapamwamba kwambiri iyenera kukhala ndi chinyezi chochepa, nthawi zambiri chimayendetsedwa pansi pa 5%.
7. Digiri ya kudziwika m'malo
Mlingo wa m'malo methoxy ndi hydroxypropoxy magulu a HPMC mwachindunji zimakhudza ntchito yake, monga solubility, gel osakaniza kutentha, mamasukidwe akayendedwe, etc. Mlingo wa m'malo angadziŵike ndi titration mankhwala kapena infuraredi spectroscopy, koma njira zimenezi ndi zovuta kwambiri ndipo ayenera kuchitidwa mu malo a labotale. Mwachidule, HPMC ndi m'malo otsika ali kusungunuka osauka ndipo akhoza kupanga gel osakaniza m'madzi.
8. Gel kutentha kuyesa
Kutentha kwa gel osakaniza a HPMC ndi kutentha komwe kumapanga gel panthawi ya kutentha. HPMC yapamwamba imakhala ndi kutentha kwa gel, kawirikawiri pakati pa 60 ° C ndi 90 ° C. Njira yoyesera kutentha kwa gel ndi:
Sungunulani HPMC m'madzi, pang'onopang'ono muwonjezere kutentha, ndikuwona kutentha komwe yankho limasintha kuchokera ku kuwonekera kupita ku turbid, komwe ndi kutentha kwa gel. Ngati kutentha kwa gel kumapatuka pamtundu wabwinobwino, zitha kutanthauza kuti kapangidwe kake ka mamolekyu kapena kulowetsa m'malo sikumakwaniritsa.
9. Kuwunika momwe ntchito ikuyendera
Kugwiritsa ntchito kwa HPMC pazifukwa zosiyanasiyana kungakhale kosiyana. Mwachitsanzo, m'makampani omanga, HPMC imagwiritsidwa ntchito ngati chosungira madzi komanso chowonjezera. Kugwiritsa ntchito kwake kusunga madzi ndi kukhuthala kumatha kuyesedwa kudzera mumatope kapena kuyesa kwa putty. M'makampani opanga mankhwala ndi zakudya, HPMC imagwiritsidwa ntchito ngati filimu yakale kapena kapisozi, ndipo mawonekedwe ake opanga mafilimu ndi colloidal amatha kuyesedwa kudzera mukuyesera.
10. Kununkhira ndi Zinthu Zosasinthika
HPMC yapamwamba siyenera kukhala ndi fungo lodziwika bwino. Ngati chitsanzocho chili ndi fungo loipa kapena kukoma kwachilendo, zikhoza kutanthauza kuti mankhwala osafunika adayambitsidwa panthawi yopanga kapena kuti ali ndi zinthu zowonongeka kwambiri. Komanso, apamwamba HPMC sayenera kutulutsa mpweya chosasangalatsa pa kutentha kwambiri.
Ubwino wa HPMC ukhoza kuweruzidwa ndi mayesero ophweka a thupi monga maonekedwe, kusungunuka ndi kuyeza kukhuthala, kapena ndi mankhwala monga kuyezetsa chiyero ndi kuyezetsa ntchito kutentha. Kupyolera mu njirazi, chigamulo choyambirira chikhoza kupangidwa pa khalidwe la HPMC, potero kuonetsetsa kuti ikugwira ntchito mokhazikika pamagwiritsidwe enieni.
Nthawi yotumiza: Sep-25-2024