HPMC imatchedwa hydroxypropyl methylcellulose.
HPMC mankhwala amasankha kwambiri koyera thonje mapadi ngati zopangira ndipo amapangidwa ndi etherification wapadera pansi zinthu zamchere.Ntchito yonseyo imamalizidwa pansi pamikhalidwe ya GMP ndikuwunika kodziwikiratu, popanda zosakaniza zilizonse monga ziwalo zanyama ndi mafuta.
HPMC katundu:
HPMC mankhwala ndi sanali ionic mapadi efa, maonekedwe ndi woyera ufa, odorless zoipa, sungunuka m'madzi ndi ambiri polar organic solvents (monga dichloroethane) ndi gawo loyenera la Mowa/madzi, propyl mowa/madzi, etc. Amadzimadzi yothetsera ali pamwamba ntchito, kuwonekera kwambiri komanso magwiridwe antchito okhazikika.HPMC ali katundu wa gel osakaniza matenthedwe, mankhwala njira madzi ndi usavutike mtima kupanga gel osakaniza mpweya, ndiyeno kusungunuka pambuyo kuzirala, specifications osiyana mankhwala gel osakaniza kutentha ndi osiyana.Solubility kusintha ndi mamasukidwe akayendedwe, m'munsi mamasukidwe akayendedwe, kwambiri solubility, specifications osiyana HPMC ali ndi kusiyana kwina mu katundu wake, HPMC m'madzi si anakhudzidwa ndi PH mtengo.Kukula kwa tinthu: 100 mesh pass rate ndi yayikulu kuposa 100%.Kachulukidwe kachulukidwe: 0.25-0.70g/ (nthawi zambiri pafupifupi 0.5g/), mphamvu yokoka yeniyeni 1.26-1.31.Kutentha kwa kutentha: 190-200 ℃, kutentha kwa carbonization: 280-300 ℃.Kuvuta kwa pamwamba: 42-56dyn / masentimita mu 2% yankho lamadzi.Ndi kuchuluka kwa methoxyl, gawo la gel limachepa, kusungunuka kwamadzi kumawonjezeka, komanso ntchito yapamtunda imakulanso.HPMC ali ndi makhalidwe thickening, salting, otsika phulusa okhutira, PH bata, posungira madzi, dimensional bata, kwambiri filimu kupanga ndi kukana kwambiri enzyme, dispersity ndi cohesiveness.
Mapulogalamu a HPMC:
1. Piritsi ❖ kuyanika: HPMC ntchito monga filimu ❖ kuyanika zakuthupi mu kukonzekera olimba, akhoza kupanga amphamvu, yosalala ndi wokongola filimu, ntchito ndende ya 2% -8%.Pambuyo kupaka, kukhazikika kwa wothandizira kuyatsa, kutentha ndi chinyezi kumawonjezeka;Zosakoma komanso zosanunkhiritsa, zosavuta kutenga, ndi mtundu wa HPMC, zoteteza ku dzuwa, zothira mafuta ndi zina zonse zogwirizana ndi zida.❖ kuyanika wamba: madzi kapena 30-80% Mowa kupasuka HPMC, ndi 3-6% yankho, kuwonjezera zosakaniza wothandiza (monga: kutentha nthaka -80, Kastor mafuta, PEG400, talc, etc.).
2. Enteric-sungunuka ❖ kuyanika kudzipatula wosanjikiza: pamwamba pa mapiritsi ndi granules, HPMC ❖ kuyanika umagwiritsidwa ntchito ngati pansi ❖ kuyanika kudzipatula wosanjikiza, ndiyeno yokutidwa ndi wosanjikiza HPMCP enteric-sungunuka zakuthupi.Kanema wa HPMC amatha kukonza kukhazikika kwa cholumikizira chosungunuka cha enteric posungira.
3. Kukonzekera kumasulidwa kosalekeza: kugwiritsa ntchito HPMC monga pore-inducing agent ndikudalira ethyl cellulose ngati mafupa a mafupa, mapiritsi a nthawi yayitali amatha kupangidwa.
4. Thickening wothandizila ndi colloid zotetezera zomatira ndi diso madontho: HPMC kwa thickening wothandizila ambiri ntchito ndende ya 0.45-1%.
5. Zomatira: HPMC monga binder ambiri ndende ya 2% -5%, ntchito kusintha bata wa zomatira hydrophobic, ambiri ntchito ndende ya 0.5-1.5%.
6. Wochedwetsa, wothandizira kumasulidwa wolamulidwa ndi woyimitsidwa.Woyimitsidwa: Mulingo wanthawi zonse wa kuyimitsidwa ndi 0.5-1.5%.
7. Food: HPMC monga thickening wothandizira anawonjezera zosiyanasiyana zakumwa, mkaka, zokometsera, zakudya zakudya, monga thickening wothandizila, binder, emulsifier, kuyimitsidwa wothandizira, stabilizer, madzi posungira wothandizira, excifer, etc.
8. Amagwiritsidwa ntchito mu zodzoladzola monga zomatira, emulsifiers, opanga mafilimu, ndi zina zotero.
Nthawi yotumiza: Jan-14-2022