Hpmc solubility

Hydroxypropyl Methyl Cellulose (HPMC), yomwe imadziwikanso kuti hypromellose, imawonetsa kusungunuka kwake komwe kumadalira kuchuluka kwake, kulemera kwake, ndi momwe amagwiritsidwira ntchito. Nthawi zambiri, HPMC imakhala yosungunuka m'madzi, yomwe ndi chinthu chofunikira kwambiri chomwe chimathandizira kusinthasintha kwake pamagwiritsidwe osiyanasiyana. Komabe, kusungunuka kungakhudzidwe ndi zinthu monga ndende ndi kutentha. Nawa malangizo ena onse:

1. Kusungunuka kwamadzi:
   • HPMC ndi sungunuka m'madzi, kupanga zomveka ndi viscous zothetsera. Kusungunuka kumeneku kumapangitsa kuti kuphatikizidwe mosavuta muzinthu zamadzimadzi monga ma gels, zonona, ndi zokutira.
2. Kudalira Kutentha:
   • Kusungunuka kwa HPMC m'madzi kumatha kutengera kutentha. Kutentha kwambiri kumawonjezera kusungunuka, ndipo mayankho a HPMC amatha kukhala owoneka bwino pakutentha kokwera.
3. Zotsatira Zoyikira:
   • HPMC nthawi zambiri imasungunuka m'madzi pamalo otsika. Komabe, pamene ndende ikuwonjezeka, kukhuthala kwa yankho kumawonjezekanso. Izi ndende amadalira mamasukidwe akayendedwe kaŵirikaŵiri ntchito zosiyanasiyana ntchito, kuphatikizapo kulamulira rheological zimatha mankhwala formulations ndi zomangamanga.
4. pH Sensitivity:
   • Ngakhale HPMC nthawi zambiri imakhala yokhazikika pamitundu yambiri ya pH, ma pH otsika kwambiri kapena apamwamba amatha kusokoneza kusungunuka kwake ndi magwiridwe ake. Nthawi zambiri amagwiritsidwa ntchito popanga mitundu yokhala ndi pH ya 3 mpaka 11.
5. Mphamvu ya Ionic:
   • Kukhalapo kwa ayoni mu yankho kungakhudze kusungunuka kwa HPMC. Nthawi zina, kuwonjezera mchere kapena ayoni ena kungakhudze khalidwe la mayankho a HPMC.

Ndikofunika kuzindikira kuti giredi yeniyeni ndi mtundu wa HPMC, komanso momwe akufunira, zitha kukhudza mawonekedwe ake a kusungunuka. Opanga nthawi zambiri amapereka malangizo ndi mafotokozedwe a kusungunuka kwa zinthu zawo za HPMC potengera izi.

Kuti mumve zambiri za kusungunuka kwa giredi inayake ya HPMC mu pulogalamu inayake, tikulimbikitsidwa kuti mufufuze pepala laukadaulo wazogulitsa kapena kulumikizana ndi wopanga kuti mumve zambiri.