Gulu: Zipangizo zokutira; Nkhani za member; Zovala za polymer yoyendetsedwa ndi polymer kuti mukonzekere kulekereratu; Wothandizira; Chithandizo choyimitsidwa, piritsi lomata; Othandizira Othandizira Otsatsa.
1. Kuyambitsa Kuyambitsa
Izi ndizosagwirizana ndi ether cylelic celluuse, zomwe zimawoneka ngati ufa woyera, wopanda fungo, wosungunuka m'madzi ndi zotupa m'madzi ozizira kuti mumveke bwino. Njira yothetsera matendawa imakhala ndi zochitika zapamwamba, kuwonekera kwambiri komanso kusakhazikika. HPMC ili ndi malo otentha. Pambuyo potenthetsa, mankhwala a madzi am'madzi a mankhwalawa pamtunda, kenako amasungunuka pambuyo pozizira. Kutentha kwa gel kuli kosiyana. Kusintha kwa kusungunuka ndi mafayilo, mamasukidwe zhao wotsika, wosungunuka wamkulu wa katundu wa HPMC ali ndi kusiyana kwa HPMC sikukhudzidwa ndi mtengo wa PH.
Kutentha kokha, kachulukidwe kanu, kachulukidwe koona ndi kutentha kwagalasi kunali 360 ℃, 0.341g / masentimita 10 ~ 180 ~ motero. Pambuyo potenthetsa, imatembenuka ku Brown 190 ~ 200 ° C ndikuwotcha pa 225 ~ 230 ° C.
HPMC ikufanana ndi yopanda chloroform, ethanol (95%), ndi maenhyl ether, ndikusungunuka mu sonanol ndi methol chloride, ndi madzi osakaniza. Mitundu ina ya hpmc imasungunuka m'maberekedwe a acetone, methylene chloride, ndi 2-propyal, komanso mokhazikika monga ma sol sol sol sol sol.
Gome 1: Zizindikiro
nchito
Geji,
60 GD (2910).
65gd (2906)
75gd (2208)
Methoxy%
28.0-32.0
27.0-30.0
19.0-24.0
Hydroxyproxy%
7.0-12.0
4.0-7.5
4.0-12.0
Kutentha Kwa GEL ℃
664.
62.0-68.0
70.0-90.0
Ma visnce phot s.
3,5,655,50,4000
50400 0
100400 0150 00100 000
Kuchepetsa Kulemera%
5.0 kapena kuchepera
Kuwotcha Reseidee%
1.5 kapena kuchepera
pH
4.0-8.0
Chitsulo cholemera
20 kapena kuchepera
arsenano
2.0 kapena kuchepera
2. Mawonekedwe a malonda
2.1 hydroxypypyl methylcellulose imasungunuka m'madzi ozizira kuti apange yankho la colloidal colloidal. Malingana ngati ikuwonjezeredwa kumadzi ozizira ndikusunthika pang'ono, imatha kusungunuka mu yankho lowonekera. M'malo mwake, zimangokhala zopanda madzi m'madzi otentha kuposa 60 ℃ ndipo imangotupa. Pokonzekera hydroxypropyll mu meticellulose yankho, ndibwino kuwonjezera gawo la madzi a hydroxnseloulose, ndipo pomaliza pakezani madzi ozizira kuti apitilize kuchuluka.
2.2 hydroxypypyl methylcellulose ndi etherse yopanda inic cell, sakugwirizana ndi mchere wa huw, kotero kuti muwonetsetse kuti HPMC siyikukonzekera.
2.3 Hydroxypypyl methylcellulose ili ndi zinthu zodziwika bwino, komanso kuchuluka kwa digiri yochokera ku kapangidwe kake, zotsatsa zimakuthandizaninso. Mankhwala ogwiritsa ntchito hpmc monga okonda amakhala ndi mtundu wokhazikika mkati mwa mankhwala osokoneza bongo pogwiritsa ntchito zikhalidwe zina zamakhalidwe (wowuma, dextrin, shuga).
2.4 Hydroxypropyll methylcellulose ndi metabrally cet. Monga zophatikizira zophatikizira, sizikukakamizidwa kapena kulowetsedwa, motero sizimapereka kutentha mu mankhwala ndi chakudya. Ili ndi ntchito yapadera yotsika mtengo wamtengo wapatali, wopanda mchere mankhwala osokoneza bongo, osadwala matenda odwala matenda ashuga.
2.5hpmc ndi yokhazikika ku macidis ndi zitsulo, koma ngati ma pH amapitilira 2 ~ 11 ndipo amakhudzidwa ndi kutentha kwambiri kapena nthawi yayitali yosungirako, kumachepetsa kuchuluka kwa chipwekiti.
2.6 Hydroxypropyll methyllulose yankho limatha kupereka zochitika zapamwamba, kuwonetsa mawonekedwe owoneka bwino komanso osagwirizana. Imakhala ndi emulsirition yogwira mtima mu dongosolo la magawo awiri ndipo limatha kugwiritsidwa ntchito ngati chokhazikika chothandiza komanso choteteza.
2.7 hydroxypropyll methyllulose yankho ili ndi katundu wabwino kwambiri wopanga mafilimu, ndipo ndi zokutira bwino mapiritsi ndi mapiritsi. Kupangika kwa nembane ndi zopanda utoto komanso kovuta. Ngati glycerol imawonjezeredwa, chipi pulasitiki chimatha kuwonjezeka. Pambuyo pa chithandizo, chomwe chimabalazidwa m'madzi ozizira, ndipo chiwerengero cha chibadwa chitha kuwongoleredwa posintha chilengedwe. Amagwiritsidwa ntchito pokonzekera kulekerera pang'onopang'ono komanso kukonzekera kokhazikika.
3..
3.1. Ogwiritsidwa ntchito ngati othandizira komanso osamala
HPMC imagwiritsidwa ntchito kulimbikitsa zosungunulira mankhwalawa komanso kuchuluka kwa mamasulidwe, kumatha kusungunuka mwachindunji kwa mtundu wa zomata ndi zosokoneza 5%.
HPMC AQQUASOOS yothetsera vuto la Ethanol kuti apange bander; Chitsanzo: 2% HPMC Aquious yankho losakanikirana ndi 55% ethanol yankho lake lidagwiritsidwa ntchito potengera makapisozi a Aoxigillin, kotero kuti kufalikira kwa AOXILININ kumawonjezeka kuchokera 38% mpaka 90% popanda HPMC.
HPMC imatha kupangidwa ndi mitundu yomatira ndi mitundu yosiyanasiyana ya wowuma wosungunuka pambuyo posungunuka; Kuwonongeka kwa erythromycin ectic-zokutidwa ndi 38.26% mpaka 97.38% pomwe 2% hpmc ndi 8% wowuma adaphatikizidwa.
2.2. Pangani mawonekedwe ophunzitsira makanema ndi mawonekedwe a filimu
Hpmc ngati mawonekedwe osungunuka madzi ali ndi mawonekedwe otsatirawa: kusinthasintha kotheratu; Njira yokutidwa ndi yosavuta; Kanema waluso wopanga katundu; Ikhoza kusunga mawonekedwe a chidutswacho, kulemba; Imatha kukhala chinyontho; Ikhoza kununkhira, kukonza kuwongolera. Izi zimagwiritsidwa ntchito ngati filimu yosungunuka yamadzi ndi mapiritsi okhala ndi mafayilo otsika, komanso kanema wophatikizika ndi mafayilo apamwamba, kuchuluka kwake ndi 2% -5%.
2.3, monga wothandizira wambiri ndi gulu la Colloidal
HPMC imagwiritsidwa ntchito ngati makulidwe okula ndi 0.45% ~ 1.0%, itha kugwiritsidwa ntchito ngati madontho amaso ndi misozi youndana; Ankawonjezera kukhazikika kwa guluu hydrophobic, kupewa tinthu tating'onoting'ono, mpweya, mlingo wamba ndi 0,5% ~ 1.5%.
2.4, monga blocker, zomasulira zomasulidwa pang'onopang'ono, zowongolera zotulutsidwa
Mtundu wa HPMC Hilcress umagwiritsidwa ntchito kukonza ma blockers ndikuwongolera matebulo osokoneza bongo osakanikirana ndi mapiritsi a hydrophilic geleleton omasulidwa. Mtundu wotsika-visccress ndi wothandizika pore-woyang'anira mapiritsi omasulidwa kapena olamulidwa kuti mumveke mobwerezabwereza, kutsatiridwa ndi kumasulidwa kapena kumasulidwa - kumasulidwa kuti ukhale wokhazikika m'magazi.
2.5. Gel ndi suctutory matrix
Ma suprostories a hydrogel ndi zomata za m'mimba amatha kukonzedwa pogwiritsa ntchito mawonekedwe a hydrogel omwe amagwiritsidwa ntchito ndi HPMC m'madzi.
2.6 zachilengedwe zomatira zida
Metronidazole idasakanikirana ndi HPMC ndi Polycabobobote 934 m'njira yosakanizira mapiritsi a bioidheaty olamulidwa ndi 250mg. Mu mayeso osokoneza a vitro adawonetsa kuti kukonzekera kosasunthika m'madzi, ndipo mankhwalawa adasulidwa ndi kusokonekera kwa magalamu a carfvion. Kukhazikitsa kwa zinyama kunawonetsa kuti dongosolo lomasulira latsopano la mankhwala linali ndi zotsatsa zotsatsa zachilengedwe kuti zizichitika ku Bovine.
2.7, monga thandizo lakukulidwa
Maonekedwe apamwamba a malonda awa ndi chida cholumikizira chabwino choyimitsidwa pamadzi kukonzekera, Mlingo wake wachizolowezi ndi 0,5% ~ 1.5%.
4. Zolemba
4.1 Filance Colung Solution Yankho: HPMC 2kg, Talc 2kg, Castor mafuta 1000ml, 3000ml, madzi 47000ml kuchuluka. Pali njira ziwiri zopangira Iwo.
4.1.1 Kukonzekera utoto wosungunuka utoto wamafuta: Onjezani kuchuluka kwa HPMC mu 95% ethanol, ilowetseni muyeso wina, sutani muyeso wina (fillect ngati kuli koyenera) Sakanizani 80% ya yankho (20% yopukutira) mafuta a Castor, 80, ndi Proyelene Glycol.
4.1.2 Kukonzekera kwa utoto (monga chitsulo cha oxide) okutidwa mu 95% ethanol usiku, ndipo madzi adawonjezedwa kuti apange yankho la 2% hpmc lowonekera. 20% ya njirayi idatengedwa yopukutidwa, ndipo zotsalazo 80% oxide adakonzedwa ndi njira yopukutira imadzimadzi, kenako kuchuluka kwa mankhwala ena adawonjezeredwa. Njira yolumikizira madzi okutira: Thirani pepala la tirigu mu mphika wokutidwa, mizere yotentha mpaka 45 ℃, mutha kuthira madzi owombera 5 ~
4.2α-Interferon Dimbrane 50μGE ya α-interferon idasungunuka mu 10ml0.0ml hydrochlc ndi 0,5gl hydrochc ndi 0,5gl hydrocloric acid Izi zimapangidwa mufilimu.
4.3 Mapiritsi a cotrimoxaxoxaxale (0.4G ± 0.08g) smz (80 mesh) 40kg, 3kg, 3KG, 3%, kenako ndi kuphatikiza 5min. Potengera 3% HPMC Aquaous yankho, zofewa, ndi ma mesh osakaniza, kuwuma, kenako ndi magnerm a 14 florate osakaniza mapiritsi. Izi zimagwiritsidwa ntchito makamaka ngati binder. Kuwonongeka kwa mapiritsi kunali 96% / 20min.
4.4 Mapiritsi (0.25g) akupaka 80 mesh 25kg, wowuma (120 mesh) 2.1kg, magnesium stearate kuchuluka koyenera. Njira yake yopanga ndikusakanikizani pivaperric acid, hpmc mokwanira, ndi 20% screncle screen, ndi vactor, kenako veter scrench free, ndi mapiritsi a 10mm.25). Ndi wowuma ngati wothandizika, chizolowezi cha piritsi ichi sichochepera 80% / 2min, chomwe chili chapamwamba kuposa zopangidwa chimodzimodzi ku Japan.
4,5 Zochita zolimbitsa thupi HPMC-4000, HPMC-4500 kapena HPMC-5000 0.3g, 10%, 10%, 10%, madzi owonjezeredwa ku 100min. Njira yake yopanga ndi HPML yoyikidwa m'madzi 15ml, 80 ~ 9 ℃ Madzi osindikizidwa ° C mpaka 8.6 ° C. Izi zimagwiritsidwa ntchito ngati kuchepa kwa misozi, zikagwiritsidwa ntchito moyenera m'chipinda cham'mimba, 0.7% ~ 1.5% ndiyoyenera.
4.6 MethOnto Fedior Auture Mapiritsi a Idthothmen Resein mchere 187.5mg, ma lactose 40.0mg, 4mg, 40-0 Imakonzedwa ngati mapiritsi mwa njira wamba. Izi zimagwiritsidwa ntchito ngati zida zomasulira.
4.7 Kwa avantomycin ⅳ mapiritsi, 2149g avintomycin ⅳ monohhyml ndi 1000ml isopropyl madzi osakaniza a 15% (5: 1) Anasakanizidwa, osakanizidwa, ndi zouma pa 35 ℃. Ma granules owuma 575g ndi 62.5g hydroxypylosellulose e-50 adasakanizidwa bwino, kenako 7.5G Stearic Osuta ndi 3.25g Stenesium Stearate adawonjezeredwa mapiritsi a Vanguard Percin ycin ycin ycin ycin ⅳcrin ⅳcrin ⅳcin ⅳcin ⅳcrin ⅳ Izi zimagwiritsidwa ntchito ngati zomasulira pang'onopang'ono.
4.8 Nifadipine adamasulidwa ma granules 1 gawo nifedipine, magawo atatu hydroxpyl cellulose ndi magawo 8 a chimanga adawonjezeredwa kuti apange granules ndi njira zapakatikati. Kumasulidwa kwa mankhwalawa kwa zigawenga sikunakhudzidwe ndi kusintha kwa Ph ndipo anali pang'onopang'ono kuposa wa granules yomwe ilipo. Pambuyo maola 12 a makonzedwe a pakamwa, magazi a anthu anali anthu 12mg / ml, ndipo kunalibe kusiyana payekha.
4.9 Pulogalamu ya Hydrochloride Sungani Kapisule prosole hydrochloride 60kg, microcrystalline cellulose 40kg, kuwonjezera madzi 50l kuti apange granules. HPMC1KG ndi EC 9kg adasakanizidwa mu solvent wosakanikirana (methylene chloride: methanol = 1: 1) Kapisozi iliyonse ili ndi 160mg ya propranolol hydrochloride zigawo.
4.10 Naprolol HCL skeleton tablets were prepared by mixing naprolol HCL :HPMC: CMC-NA at the ratio of 1:0.25:2.25. Kumasulidwa kwa mankhwalawa kunali pafupi ndi zero pasanathe maola 12.
Mankhwala ena amathanso kupanga zida zosakanizidwa, monga metoprolol: HPMC: CMC-na malinga ndi: 1: 1.25: 1.25; Allylprolol: hpmc malinga ndi 1: 2.8: 2.92 Vetio. Kumasulidwa kwa mankhwalawa kunali pafupi ndi zero pasanathe maola 12.
4.11 Mapiritsi a Skeleton a Zida zosakanizidwa za ethylaminine zotumphukira zomwe zimakonzedwa ndi njira yosakanikirana pogwiritsa ntchito osakaniza a micro gel: cmc-n: hpmc 1: 0.7: 4.4. Mankhwalawa amatha kumasulidwa 12h mu vitro ndi ku Vivo, ndipo njira yomasulira ili ndi mgwirizano wabwino. Zotsatira za mayeso othamanga molingana ndi malamulo a FDa amalosera kuti moyo wosungirako mankhwalawa ali ndi zaka ziwiri.
4.12 HPMC (5MPAIJ) (magawo 5), HPMC (4000 MPPI') ndi zigawo 6 Acetaminophen ndi 60 Silika Gel adawonjezeredwa, ndipo utsi wowuma. Izi zili ndi 80% yamankhwala akuluakulu.
4.13 Theophylline hydrophilic gel sleton mapiritsi omwe amawerengedwa malinga ndi zolemera zonse, 18% -35% hpmc, zomwe zingakhalebe ndi magazi olamulidwa ndi thupi la anthu kwa 12h Pambuyo pokonza pakamwa.
Post Nthawi: Feb-05-2024