Hypromellose, yomwe imadziwikanso kuti hydroxypropyl methylcellulose (HPMC), ndi polima yosinthika kwambiri yochokera ku cellulose. Chifukwa cha mankhwala ake apadera komanso thupi, HPMC imagwiritsidwa ntchito ngati thickener, stabilizer ndi zomatira m'mafakitale a mankhwala, chakudya ndi chisamaliro chaumwini. M'nkhaniyi, tikambirana za chemistry ya HPMCs ndi ntchito zawo zofunika.
1. Kusungunuka
Chimodzi mwa zinthu zofunika kwambiri mankhwala katundu wa HPMC ndi solubility ake. HPMC imasungunuka m'madzi ndi zosungunulira zambiri za organic, zomwe zimapangitsa kuti ikhale chigawo chabwino cha machitidwe operekera mankhwala ndi ntchito zina zomwe zimafuna kusungunuka. Komabe, kusungunuka kwa HPMC kumatsimikiziridwa ndi kuchuluka kwake (DS), komwe kumatsimikizira kuchuluka kwa magulu a hydroxypropyl ndi methyl omwe amapezeka mu unyolo wa polima. Ma HPMC omwe ali ndi DS apamwamba amakhala ndi kusungunuka kochepa chifukwa cha kuchuluka kwa ma intermolecular.
2. Rheology
Chinthu china chofunika kwambiri cha mankhwala a HPMC ndi khalidwe lake la rheological. HPMC luso kupanga gel osakaniza-ngati maukonde pa hydration angagwiritsidwe ntchito kulamulira mamasukidwe akayendedwe ndi otaya makhalidwe a formulations. HPMC imawonetsanso machitidwe omwe si a Newtonian otaya, kutanthauza kuti mamasukidwe ake amasinthasintha malinga ndi kumeta ubweya wogwiritsidwa ntchito. Katunduyu atha kuwongoleredwanso posintha kuchuluka kwa HPMC ndi DS popanga.
3. Kupanga mafilimu
HPMC imagwiritsidwanso ntchito kwambiri ngati filimu yakale chifukwa imatha kupanga mafilimu ofananira akagwiritsidwa ntchito pagawo. Mafilimu opanga mafilimu a HPMC amadalira DS, kukhuthala kwake komanso kukhalapo kwa plasticizers, zomwe zingapangitse kusinthasintha ndi kusinthasintha kwa filimuyo. Makanema opangidwa kuchokera ku HPMC amagwiritsidwa ntchito kwambiri popereka mankhwala chifukwa amalola kutulutsa koyendetsedwa bwino kwa zinthu zomwe zimagwira ntchito.
4. Kugwirizana
HPMC ndi excipient yogwirizana kwambiri ndipo angagwiritsidwe ntchito zosiyanasiyana formulations. Zimagwirizana ndi zosakaniza zambiri za mankhwala, kuphatikizapo zosakaniza zogwiritsira ntchito mankhwala (APIs) ndi zina zowonjezera zomwe zimagwiritsidwa ntchito popanga mankhwala. HPMC imagwirizananso ndi zosakaniza zambiri zazakudya, zomwe zimapangitsa kukhala chisankho chodziwika bwino pazakudya.
5. Kukhazikika kwa mankhwala
HPMC ndi khola polima kuti kukana hydrolysis ndi zina zimachitikira mankhwala. Kukhazikika kumeneku kumapangitsa kuti ikhale yothandiza kwambiri pamachitidwe operekera mankhwala chifukwa imateteza zomwe zimagwira ntchito kuti zisawonongeke ndikuwonjezera bioavailability. Komabe, kukhazikika kwa mankhwala a HPMC kungakhudzidwe ndi kutentha kwakukulu, chinyezi chachikulu, ndi zosungunulira zina, zomwe zingayambitse polima kuti ziwonongeke komanso kuchepetsa mphamvu zake muzopanga.
6. Biocompatibility
Pomaliza, HPMC ndi polima yogwirizana kwambiri ndi biocompatible yomwe ili yotetezeka kuti igwiritsidwe ntchito muzamankhwala ndi zinthu zosamalira anthu. Ndiwopanda poyizoni, wosakhala ndi immunogenic komanso wosawonongeka, ndikupangitsa kuti ikhale yoyenera pamapangidwe omwe amafunikira kawopsedwe kakang'ono komanso chitetezo chokwanira.
Mwachidule, HPMC hypromellose ndi polima multifunctional ndi osiyanasiyana zofunika mankhwala katundu, kuphatikizapo solubility, rheology, mafilimu kupanga katundu, ngakhale, kukhazikika kwa mankhwala, ndi biocompatibility. Zinthu izi zimapangitsa kukhala kothandiza kwambiri pamakina operekera mankhwala ndi ntchito zina m'mafakitale azakudya ndi chisamaliro chamunthu. Pamene kafukufuku akupitiriza kukulitsa kumvetsetsa kwathu kwa HPMCs, katundu wawo wapadera angapeze ntchito zambiri m'tsogolomu.
Nthawi yotumiza: Jul-28-2023