Hydroxypropyl Methylcellulose (HPMC) ndi polima wosunthika wogwiritsidwa ntchito m'mafakitale osiyanasiyana kuphatikiza mankhwala, zomangamanga, chakudya, ndi zodzola.Amachokera ku cellulose, polima wachilengedwe wopezeka muzomera.HPMC imayamikiridwa kwambiri chifukwa chopanga mafilimu, kukhuthala, kukhazikika, komanso kusunga madzi.M'makampani opanga mankhwala, amagwiritsidwa ntchito ngati chithandizo chamankhwala m'mitundu yamankhwala amkamwa, kukonzekera kwamaso, ma topical formulations, ndi njira zowongolera zoperekera mankhwala.
HPMC akhoza m'gulu kutengera magawo angapo kuphatikizapo kulemera kwa maselo, digiri ya m'malo, ndi tinthu kukula.Nazi mwachidule mitundu yosiyanasiyana ya HPMC kutengera magawo awa:
Kutengera kulemera kwa Molecular:
High Molecular Weight HPMC: Mtundu uwu wa HPMC uli ndi kulemera kwakukulu kwa maselo, zomwe zimatsogolera ku kukhuthala kwamphamvu komanso kupanga mafilimu.Nthawi zambiri amagwiritsidwa ntchito pomwe ma viscosity apamwamba amafunikira, monga momwe amapangidwira omasulidwa.
Low Molecular Weight HPMC: Mosiyana, otsika maselo kulemera HPMC ali otsika mamasukidwe akayendedwe kukhuthala ndipo amagwiritsidwa ntchito pamene m'munsi mamasukidwe akayendedwe ndi kusungunuka mofulumira amafuna.
Kutengera Degree of Substitution (DS):
High Substitution HPMC (HPMC-HS): HPMC yokhala ndi m'malo mwapamwamba kwambiri imawonetsa kusungunuka kwabwinoko m'madzi ndipo imatha kugwiritsidwa ntchito m'mapangidwe omwe amafunikira kusungunuka mwachangu.
Medium Substitution HPMC (HPMC-MS): Mtundu uwu wa HPMC umapereka malire pakati pa kusungunuka ndi kukhuthala.Amagwiritsidwa ntchito popanga mankhwala osiyanasiyana.
Low Substitution HPMC (HPMC-LS): HPMC yokhala ndi digiri yotsika yolowa m'malo imapereka kusungunuka kwapang'onopang'ono komanso kukhuthala kwapamwamba.Nthawi zambiri amagwiritsidwa ntchito m'mawonekedwe a mlingo wokhazikika.
Kutengera Kukula kwa Tinthu:
Fine Particle Size HPMC: HPMC yokhala ndi tinthu tating'onoting'ono imapereka mawonekedwe abwino oyenda ndipo nthawi zambiri imakonda mumitundu yolimba monga mapiritsi ndi makapisozi.
Coarse Particle Size HPMC: Tinthu tating'onoting'ono ndi oyenera kugwiritsa ntchito komwe kumasulidwa koyendetsedwa kapena kutulutsidwa kwanthawi yayitali kumafunidwa.Amagwiritsidwa ntchito kwambiri pamapiritsi a matrix ndi ma pellets.
Maphunziro apadera:
Enteric HPMC: Mtundu uwu wa HPMC umapangidwa mwapadera kuti usagwirizane ndi madzi am'mimba, zomwe zimapangitsa kuti zidutse m'mimba ndi kutulutsa mankhwala m'matumbo.Amagwiritsidwa ntchito kwambiri pamankhwala omwe amakhudzidwa ndi pH ya m'mimba kapena popereka zomwe akufuna.
Kutulutsidwa Kokhazikika kwa HPMC: Mapangidwe awa adapangidwa kuti atulutse chinthu chogwira ntchito pang'onopang'ono pakapita nthawi yayitali, zomwe zimapangitsa kuti azitha kugwiritsa ntchito mankhwala kwanthawi yayitali komanso kuchepetsa kuchuluka kwa mlingo.Amagwiritsidwa ntchito nthawi zambiri pakanthawi kochepa komwe kumakhala kofunikira pakusunga kuchuluka kwa mankhwala m'magazi.
Magulu Ophatikiza:
HPMC-Acetate Succinate (HPMC-AS): Mtundu uwu wa HPMC umaphatikiza zinthu za HPMC ndi magulu a acetyl, kuti zikhale zoyenera kwa zokutira za enteric ndi machitidwe operekera mankhwala okhudzidwa ndi pH.
HPMC-Phthalate (HPMC-P): HPMC-P ndi polima wodalira pH omwe amagwiritsidwa ntchito popaka ma enteric kuteteza mankhwalawa ku acidic m'mimba.
Zosakaniza Mwamakonda Anu:
Opanga atha kupanga zosakanikirana makonda a HPMC ndi ma polima ena kapena zothandizira kuti akwaniritse zofunikira za kapangidwe kake monga kuwongolera kutulutsa kwamankhwala, kukhazikika kokhazikika, kapena mawonekedwe abwinoko opaka kukoma.
mitundu yosiyanasiyana ya HPMC imalola kuti igwiritsidwe ntchito mumitundu yambiri yamankhwala, iliyonse yokonzedwa kuti ikwaniritse zofunikira zenizeni monga kusungunuka, kukhuthala, kutulutsa kinetics, ndi kukhazikika.Kumvetsetsa mitundu yosiyanasiyana ya HPMC ndi mawonekedwe ake ndikofunikira kuti opanga apange njira zoperekera mankhwala zogwira mtima komanso zokometsedwa.
Nthawi yotumiza: Mar-19-2024