Carbomer ndi hydroxyethylcellulose (HEC) onse ndi zosakaniza zomwe zimagwiritsidwa ntchito nthawi zambiri m'mafakitale osiyanasiyana, makamaka muzodzola, mankhwala, ndi zinthu zosamalira anthu. Ngakhale kuti amagwiritsidwa ntchito mofananamo monga zowonjezera zowonjezera ndi zolimbitsa thupi, ali ndi mitundu yosiyanasiyana ya mankhwala, katundu, ndi ntchito.
1. Mapangidwe a Chemical:
Carbomer: Ma Carbomer ndi ma polima olemera kwambiri a ma acrylic acid olumikizidwa ndi ma polyalkenyl ether kapena divinyl glycol. Amapangidwa ndi polymerization reaction.
Hydroxyethylcellulose: Hydroxyethylcellulose, kumbali ina, imachokera ku cellulose, polima yochitika mwachilengedwe. Amapangidwa pochiza cellulose ndi sodium hydroxide ndi ethylene oxide kuti ayambitse magulu a hydroxyethyl pamsana wa cellulose.
2. Kapangidwe ka Mamolekyu:
Carbomer: Ma Carbomers ali ndi nthambi zama cell chifukwa cha mawonekedwe awo olumikizana. Nthambi iyi imathandizira kuti athe kupanga maukonde atatu-dimensional pamene ali ndi hydrated, zomwe zimapangitsa kuti zikhale zolimba komanso zowonongeka.
Hydroxyethylcellulose: Hydroxyethylcellulose imasunga mawonekedwe a cellulose, ndi magulu a hydroxyethyl omwe amamangiriridwa ku mayunitsi a shuga m'mphepete mwa tcheni cha polima. Dongosolo la mzerewu limakhudza machitidwe ake monga thickener ndi stabilizer.
3. Kusungunuka:
Carbomer: Ma Carbomers nthawi zambiri amaperekedwa mu mawonekedwe a ufa ndipo sasungunuka m'madzi. Komabe, amatha kutupa ndi kuthira madzi m'madzi amadzimadzi, kupanga ma gels owonekera kapena ma viscous dispersions.
Hydroxyethylcellulose: Hydroxyethylcellulose imaperekedwanso ngati ufa koma imasungunuka mosavuta m'madzi. Imasungunuka kuti ipange mayankho omveka bwino kapena osasunthika pang'ono, kutengera ndende ndi zigawo zina zomwe zimapangidwira.
4. Makulidwe Katundu:
Carbomer: Ma Carbomer ndi okhuthala bwino kwambiri ndipo amatha kupanga kukhuthala kwamitundu yosiyanasiyana, kuphatikiza zonona, ma gels, ndi mafuta odzola. Amapereka zinthu zabwino zoyimitsa ndipo nthawi zambiri amagwiritsidwa ntchito kukhazikika emulsions.
Hydroxyethylcellulose: Hydroxyethylcellulose imagwiranso ntchito ngati thickener koma imasonyeza khalidwe losiyana la rheological poyerekeza ndi carbomers. Amapereka pseudoplastic kapena kumeta ubweya wonyezimira ku mapangidwe, kutanthauza kuti kukhuthala kwake kumachepetsa pansi pa kumeta ubweya, kumathandizira kugwiritsa ntchito mosavuta ndikufalikira.
5. Kugwirizana:
Carbomer: Ma Carbomers amagwirizana ndi mitundu yosiyanasiyana ya zodzikongoletsera komanso ma pH. Komabe, angafunike neutralization ndi alkalis (mwachitsanzo, triethanolamine) kukwaniritsa mulingo woyenera thickening ndi gelling katundu.
Hydroxyethylcellulose: Hydroxyethylcellulose imagwirizana ndi zosungunulira zosiyanasiyana komanso zopangira zodzikongoletsera. Ndiwokhazikika pa pH yotakata ndipo safuna kusalowerera ndale kuti kunenepa.
6. Malo Ogwiritsira Ntchito:
Carbomer: Carbomers amapeza kugwiritsidwa ntchito kwambiri pazinthu zosamalira anthu monga mafuta opaka, mafuta odzola, ma gels, ndi makonzedwe osamalira tsitsi. Amagwiritsidwanso ntchito muzinthu zamankhwala monga ma gels apakhungu ndi ophthalmic solutions.
Hydroxyethylcellulose: Hydroxyethylcellulose imagwiritsidwa ntchito kwambiri popanga zodzikongoletsera komanso zosamalira munthu, kuphatikiza ma shampoos, zoziziritsa kukhosi, zotsukira thupi, ndi mankhwala otsukira mano. Amagwiritsidwanso ntchito pazamankhwala, makamaka m'mapangidwe apakhungu.
7. Zomverera:
Carbomer: Ma gels a Carbomer nthawi zambiri amawonetsa mawonekedwe osalala komanso opaka mafuta, omwe amapereka chidziwitso chofunikira pamapangidwe. Komabe, nthawi zina amatha kumva kuti ndizovuta kapena zomata pakugwiritsa ntchito.
Hydroxyethylcellulose: Hydroxyethyl cellulose imapangitsa kumva kwa silky komanso kosamata pamapangidwe. Kachitidwe kake kakumeta ubweya wa ubweya kumathandizira kufalikira ndi kuyamwa mosavuta, kumapangitsa kuti ogwiritsa ntchito azidziwa bwino.
8. Mfundo Zoyendetsera:
Carbomer: Ma Carbomers amadziwika kuti ndi otetezeka (GRAS) ndi akuluakulu oyang'anira akagwiritsidwa ntchito molingana ndi machitidwe abwino opanga (GMP). Komabe, zofunikira pakuwongolera zitha kusiyanasiyana kutengera zomwe akufuna komanso madera.
Hydroxyethylcellulose: Hydroxyethylcellulose imatengedwanso kuti ndi yotetezeka kuti igwiritsidwe ntchito muzodzoladzola ndi mankhwala, ndi kuvomereza kovomerezeka kuchokera kwa akuluakulu oyenerera. Kutsatira malamulo ndi malangizo ofunikira ndikofunikira pakuwonetsetsa kuti zinthu zili zotetezeka komanso zogwira mtima.
pamene onse a carbomer ndi hydroxyethylcellulose amatumikira monga thickeners ogwira ndi stabilizers mu formulations zosiyanasiyana, iwo amasiyana mawu zikuchokera mankhwala, kapangidwe maselo, solubility, thickening katundu, ngakhale, madera ntchito, makhalidwe zomverera, ndi kuganizira malamulo. Kumvetsetsa kusiyana kumeneku n'kofunika kwambiri kuti okonza mapulani asankhe chinthu choyenera kwambiri malinga ndi zomwe akufuna komanso momwe angagwiritsire ntchito.
Nthawi yotumiza: Apr-18-2024