Hydroxypropylmethylcellulose (HPMC) ndi carboxymethylcellulose (CMC) ndi mitundu iwiri yosiyana ya ma polima omwe amagwiritsidwa ntchito popanga madontho a diso, omwe nthawi zambiri amagwiritsidwa ntchito kuthetsa zizindikiro za maso owuma. Ngakhale amagawana zofanana, mitundu iwiriyi ili ndi kusiyana koonekeratu pamapangidwe awo amankhwala, katundu, njira yochitira, ndi ntchito zachipatala.
Hydroxypropyl methylcellulose (HPMC) madontho a maso:
1.Mapangidwe a Chemical:
HPMC ndi chochokera ku cellulose, polima wachilengedwe wopezeka m'makoma a cellulose.
Magulu a Hydroxypropyl ndi methyl amalowetsedwa mu cellulose, kupatsa HPMC katundu wapadera.
2. Viscosity ndi rheology:
Madontho a maso a HPMC nthawi zambiri amakhala ndi kukhuthala kwakukulu kuposa madontho ena ambiri opaka diso.
Kuwonjezeka kwa viscosity kumathandizira madontho kukhalabe pamtunda wautali, kupereka mpumulo wautali.
3. Njira yochitira:
HPMC imapanga gawo lodzitchinjiriza komanso lopaka mafuta pakhungu, kuchepetsa mikangano ndikuwongolera kukhazikika kwa kanema wamisozi.
Zimathandiza kuthetsa zizindikiro za maso owuma poletsa kutuluka kwa misozi.
4. Kugwiritsa ntchito kuchipatala:
Madontho a maso a HPMC amagwiritsidwa ntchito pochiza matenda a maso.
Amagwiritsidwanso ntchito pochita maopaleshoni a ophthalmic ndi maopaleshoni kuti asunge corneal hydration.
5. Ubwino:
Chifukwa cha kukhuthala kwapamwamba, imatha kukulitsa nthawi yokhalamo pamtunda wa ocular.
Amathetsa bwino zizindikiro za maso owuma ndipo amapereka chitonthozo.
6. Zoipa:
Anthu ena amatha kuona masomphenya atangoikidwa kumene chifukwa cha kukhuthala kwakukulu.
Madontho a maso a Carboxymethylcellulose (CMC):
1.Mapangidwe a Chemical:
CMC ndi chotuluka china cha cellulose chosinthidwa ndi magulu a carboxymethyl.
Kuyambitsidwa kwa gulu la carboxymethyl kumawonjezera kusungunuka kwamadzi, kupangitsa CMC kukhala polima wosungunuka m'madzi.
2. Viscosity ndi rheology:
Madontho a maso a CMC nthawi zambiri amakhala ndi mawonekedwe otsika poyerekeza ndi madontho a maso a HPMC.
M'munsi mamasukidwe akayendedwe amalola instillation mosavuta ndi mofulumira kufalikira pa ocular pamwamba.
3. Njira yochitira:
CMC imagwira ntchito ngati mafuta onunkhira komanso onyezimira, ndikuwongolera kukhazikika kwa kanema wamisozi.
Zimathandiza kuthetsa zizindikiro za maso owuma polimbikitsa kusunga chinyezi pamwamba pa maso.
4. Kugwiritsa ntchito kuchipatala:
Madontho a maso a CMC amagwiritsidwa ntchito kwambiri kuthetsa zizindikiro za maso owuma.
Nthawi zambiri amalangizidwa kwa anthu omwe ali ndi vuto la diso lochepa kapena lochepa.
5. Ubwino:
Chifukwa cha kukhuthala kwake kochepa, imafalikira mofulumira ndipo imakhala yosavuta kugwa.
Mogwira mtima komanso mwachangu amathetsa zizindikiro za maso youma.
6. Zoipa:
Kuchulukitsa pafupipafupi kungafunike poyerekeza ndi mapangidwe apamwamba a viscosity.
Zokonzekera zina zimatha kukhala ndi nthawi yayifupi yochitapo kanthu pamtunda.
Kuyerekeza kuyerekeza:
1. Viscosity:
HPMC ili ndi mamasukidwe apamwamba, opereka chithandizo chokhalitsa komanso chitetezo chokhazikika.
CMC ili ndi mamasukidwe otsika, omwe amalola kufalikira mwachangu komanso kuyika kosavuta.
2. Nthawi yochitapo kanthu:
HPMC nthawi zambiri imapereka nthawi yayitali yochitapo kanthu chifukwa cha kukhuthala kwake kwapamwamba.
CMC ingafunike kumwa pafupipafupi, makamaka ngati diso louma kwambiri.
3. Chitonthozo cha odwala:
Anthu ena angapeze kuti madontho a maso a HPMC poyamba amachititsa kusawona kwakanthawi chifukwa cha kukhuthala kwawo kwakukulu.
Madontho a maso a CMC nthawi zambiri amalekerera bwino ndipo amayambitsa kusawoneka koyambirira.
4. Malangizo azachipatala:
HPMC imalimbikitsidwa kwa anthu omwe ali ndi vuto la diso lolimba kapena lowuma kwambiri.
CMC imagwiritsidwa ntchito ngati maso owuma pang'ono kapena owuma komanso kwa iwo omwe amakonda mawonekedwe ocheperako.
Hydroxypropylmethylcellulose (HPMC) ndi carboxymethylcellulose (CMC) madontho a maso ndi njira zofunika kwambiri pochiza matenda a maso owuma. Kusankha pakati pa ziwirizi kumadalira zofuna za wodwala, kuopsa kwa diso louma, ndi nthawi yomwe akufuna kuchitapo kanthu. Kukhuthala kwapamwamba kwa HPMC kumapereka chitetezo chokhalitsa, pomwe kukhuthala kwa CMC kumapereka mpumulo mwachangu ndipo kungakhale chisankho choyamba kwa anthu omwe ali ndi vuto la kusawona bwino. Ophthalmologists ndi osamalira maso nthawi zambiri amaganizira izi posankha madontho oyenera opaka mafuta kwa odwala awo, opangidwa kuti apititse patsogolo chitonthozo ndikuchotsa bwino zizindikiro zamaso owuma.
Nthawi yotumiza: Dec-25-2023