Hydroxypropyl Methyl Cellulose (HPMC), yemwe amadziwikanso ndi dzina lamalonda la hypromellose, ndi polima wopangidwa kuchokera ku cellulose wachilengedwe. Gwero lalikulu la cellulose popanga HPMC nthawi zambiri ndi zamkati kapena thonje. Njira yopangirayi imaphatikizapo kusintha kwa cellulose kudzera mu etherification, kuyambitsa magulu a hydroxypropyl ndi methyl pamsana wa cellulose.

Kupanga kwa HPMC kumaphatikizapo njira zingapo:

1. Kutulutsa Ma cellulose:
   • Ma cellulose amachokera ku zomera, makamaka zamkati kapena thonje. Ma cellulose amachotsedwa ndikuyeretsedwa kuti apange cellulose zamkati.
2. Alkalization:
   • Ma cellulose zamkati amathandizidwa ndi njira ya alkaline, nthawi zambiri sodium hydroxide (NaOH), kuti ayambitse magulu a hydroxyl pa unyolo wa cellulose.
3. Etherification:
   • Etherification ndiye gawo lofunikira popanga HPMC. Ma cellulose a alkalized amachitidwa ndi propylene oxide (yamagulu a hydroxypropyl) ndi methyl chloride (yamagulu a methyl) kuti adziwitse magulu a etherwa pamsana wa cellulose.
4. Neutralization ndi Kuchapa:
   • Chotsatira chosinthidwa cha cellulose, chomwe tsopano ndi Hydroxypropyl Methyl Cellulose, chimakhala ndi ndondomeko ya neutralization kuchotsa alkali iliyonse yotsala. Kenako imatsukidwa bwino kuti ichotse zonyansa ndi zinthu zina.
5. Kuyanika ndi Kugaya:
   • Ma cellulose osinthidwa amawumitsidwa kuti achotse chinyezi chochulukirapo ndipo kenako amagayidwa kukhala ufa wabwino. The tinthu kukula akhoza lizilamuliridwa zochokera anafuna ntchito.

Chotsatira cha HPMC chopangidwa ndi ufa woyera kapena wopanda-woyera wokhala ndi madigiri osiyanasiyana a hydroxypropyl ndi methyl substitution. Makhalidwe enieni a HPMC, monga kusungunuka kwake, kukhuthala kwake, ndi machitidwe ena, zimadalira kuchuluka kwa kulowetsedwa ndi kupanga.

Ndikofunikira kudziwa kuti HPMC ndi polima yopangidwa ndi semi-synthetic, ndipo ngakhale imachokera ku cellulose yachilengedwe, imasinthidwa kwambiri pamakina opanga kuti akwaniritse zomwe akufuna pazogwiritsa ntchito zosiyanasiyana zamafakitale.