Hydroxypropyl methylcellulose (HPMC) ndi polima yosunthika yomwe imagwiritsidwa ntchito kwambiri m'makampani opanga mankhwala, makamaka pamapangidwe amapiritsi.Monga chochokera ku cellulose, HPMC ili ndi zinthu zingapo zogwira ntchito zomwe zimathandizira pakugwira ntchito kwa piritsi lonse.Chigawocho chimachokera ku cellulose kudzera muzosintha zingapo za mankhwala, zomwe zimapangitsa kuti pakhale mankhwala omwe ali ndi zinthu zapadera zomwe zimayenera kugwiritsidwa ntchito mosiyanasiyana.M'mapangidwe a mapiritsi, HPMC ili ndi ntchito zosiyanasiyana, kuphatikizapo kulamulira kutulutsidwa kwa mankhwala, kukonza mgwirizano wa mapiritsi, ndi kupititsa patsogolo kukhazikika kwa mawonekedwe a mlingo.
1. Zomanga ndi granulating agents:
HPMC imagwira ntchito ngati chomangira pamapangidwe a piritsi, kuthandiza kumangiriza zosakanizazo ndikuletsa kupasuka msanga kwa piritsi.Amagwiritsidwanso ntchito ngati granulating wothandizira panthawi yopanga, kuthandiza mankhwala osakaniza ndi osakaniza kuti apange granules.
2. Matrix opanga ma matrix kuti atulutsidwe molamulidwa:
Ubwino umodzi waukulu wogwiritsa ntchito HPMC pakupanga mapiritsi ndikutha kuwongolera kutulutsidwa kwa mankhwala.Ikagwiritsidwa ntchito ngati matrix wakale, HPMC imapanga matrix ngati gel ikakumana ndi madzi, zomwe zimalola kuti mankhwalawa atulutsidwe mokhazikika komanso mowongolera.Izi ndizofunikira makamaka kwa mankhwala omwe ali ndi mazenera opapatiza ochizira kapena omwe amafunikira kuchitapo kanthu nthawi yayitali.
3. Wosokoneza:
Kuphatikiza pa ntchito yake ngati chomangira, HPMC imagwiranso ntchito ngati disintegrant mukupanga mapiritsi.Piritsi ikakumana ndi madzi am'mimba, HPMC imatupa ndikusokoneza kapangidwe ka piritsi, kulimbikitsa kutulutsidwa kwamankhwala mwachangu.Izi ndizothandiza makamaka pamapangidwe omwe atulutsidwa posachedwa.
4. Kupaka filimu:
HPMC imagwiritsidwa ntchito popaka filimu yamapiritsi.HPMC imapanga mafilimu omwe amawonjezera maonekedwe a mapiritsi, amapereka chitetezo kuzinthu zachilengedwe, komanso angagwiritsidwe ntchito pobisala kukoma.Njira yopaka filimuyi ndikugwiritsa ntchito njira ya HPMC pamwamba pamapiritsi ndikupanga zokutira yunifolomu komanso zowonekera pambuyo poyanika.
5. Control porosity ndi permeability modifiers:
Mapiritsi angafune enieni porosity ndi permeability makhalidwe kukwaniritsa kufunika Kusungunuka mbiri.HPMC angagwiritsidwe ntchito kusintha porosity ndi permeability mapiritsi, zimakhudza kumasulidwa kwa mankhwala.Izi ndizofunikira kuti mukwaniritse mbiri ya pharmacokinetic ya mankhwalawa.
6. Mafuta a Tablet:
HPMC imagwira ntchito ngati mafuta a piritsi, kuchepetsa mikangano pakati pa mapiritsi ndi zida zopangira zida panthawi yopanga.Izi zimathandizira kupanga bwino kwa piritsi ndikuwonetsetsa kuti mapiritsi samamatira ku zida.
7. Zomatira:
M'mapangidwe ena, makamaka popereka mankhwala a buccal kapena oral mucosal, HPMC angagwiritsidwe ntchito ngati wothandizira mucoadhesive.Imathandiza kutalikitsa okhala nthawi ya mlingo mawonekedwe pa mucosal pamwamba, potero utithandize mayamwidwe mankhwala.
8. Kukhazikika kwamphamvu:
HPMC kumathandiza kukhazikika kwa mapiritsi formulations poletsa mayamwidwe chinyezi ndi kuteteza mankhwala ku zinthu zachilengedwe.Izi ndizofunikira makamaka kwa mankhwala omwe amakhudzidwa ndi chinyezi kapena amatha kuwonongeka.
9. Kugwirizana ndi ena excipients:
HPMC ili ndi kuyanjana kwabwino ndi zinthu zosiyanasiyana zomwe zimagwiritsidwa ntchito popanga mapiritsi.Ngakhale izi facilitates yosavuta chiphunzitso mapiritsi ndi zosiyanasiyana mankhwala zinthu ndi zosakaniza zina.
Hydroxypropyl methylcellulose (HPMC) imagwira ntchito yofunika kwambiri popanga mapiritsi, kupereka ntchito zingapo zomwe zimathandizira kukonza magwiridwe antchito ndi mphamvu ya mawonekedwe a mlingo.Ntchito zimachokera ku zomangira ndi ma granulating agents kupita ku matrix opangidwa ndi owongolera, zida zokutira zamakanema, zothira mafuta ndi zowonjezera zokhazikika.Kusinthasintha kwa HPMC kumapangitsa kuti ikhale yofunikira pamapangidwe amankhwala, ndipo kugwiritsidwa ntchito kwake kosalekeza kumawonetsa kufunikira kwake pakukwaniritsa zomwe mukufuna popereka mankhwala.
Nthawi yotumiza: Dec-25-2023