Hydroxypropylmethylcellulose (HPMC), monga hydrophilic polima yomwe imagwiritsidwa ntchito kwambiri m'makampani opanga mankhwala, imagwiritsidwa ntchito kwambiri pakupaka mapiritsi, kutulutsa koyendetsedwa ndi njira zina zoperekera mankhwala.Chimodzi mwa zinthu zofunika kwambiri za HPMC ndi kuthekera kwake kusunga madzi, zomwe zimakhudza ntchito yake ngati wothandizira mankhwala.M'nkhaniyi, tiwona zinthu zazikulu zomwe zimakhudza kusungidwa kwa madzi kwa HPMC, kuphatikiza kulemera kwa maselo, mtundu wolowa m'malo, kukhazikika, ndi pH.
kulemera kwa maselo
Kulemera kwa mamolekyu a HPMC kumagwira ntchito yofunika kwambiri pozindikira mphamvu yake yosungira madzi.Ambiri, mkulu maselo kulemera HPMC kwambiri hydrophilic kuposa otsika maselo kulemera HPMC ndipo akhoza kuyamwa madzi ambiri.Izi ndichifukwa choti ma HPMC ali ndi unyolo wautali womwe ungathe kulumikiza ndikupanga maukonde ochulukirapo, ndikuwonjezera kuchuluka kwa madzi omwe amatha kuyamwa.Komabe, tisaiwale kuti mkulu kwambiri maselo kulemera HPMC adzayambitsa mavuto monga mamasukidwe akayendedwe ndi processing zovuta.
njira ina
Chinthu china chomwe chimakhudza mphamvu yosungira madzi ya HPMC ndi mtundu wa m'malo.HPMC nthawi zambiri imabwera m'njira ziwiri: hydroxypropyl-substituted ndi methoxy-substituted.Mtundu wolowetsedwa m'malo wa hydroxypropyl uli ndi mphamvu yoyamwa madzi kwambiri kuposa mtundu wa methoxy-substituted.Izi ndichifukwa choti gulu la hydroxypropyl lomwe lili mu molekyulu ya HPMC ndi hydrophilic ndipo limawonjezera kuyanjana kwa HPMC pamadzi.Mosiyana ndi izi, mtundu wa methoxy-substituted ndi wocheperako wa hydrophilic ndipo motero uli ndi mphamvu zochepa zosungira madzi.Chifukwa chake, mitundu ina ya HPMC iyenera kusankhidwa mosamala potengera zomwe mukufuna pazomaliza.
ganizirani kwambiri
Kuchuluka kwa HPMC kumakhudzanso mphamvu yake yosungira madzi.Pazochepa kwambiri, HPMC sipanga mawonekedwe ngati gel osakaniza, kotero mphamvu yake yosungira madzi ndi yochepa.Pamene kuchuluka kwa HPMC kumachulukirachulukira, mamolekyu a polima adayamba kutsekeka, ndikupanga mawonekedwe ngati gel.Netiweki ya gel iyi imatenga ndikusunga madzi, ndipo mphamvu yosungira madzi ya HPMC imawonjezeka ndi ndende.Komabe, ziyenera kudziwidwa kuti kuchuluka kwambiri kwa HPMC kumabweretsa zovuta zamapangidwe monga mamasukidwe akayendedwe ndi zovuta pakukonza.Chifukwa chake, kuchuluka kwa HPMC komwe kumagwiritsidwa ntchito kuyenera kukulitsidwa kuti mukwaniritse zomwe mukufuna kusunga madzi ndikupewa zovuta zomwe tatchulazi.
Mtengo wapatali wa magawo PH
Phindu la pH la malo omwe HPMC imagwiritsidwa ntchito lidzakhudzanso mphamvu yake yosungira madzi.Mapangidwe a HPMC ali ndi magulu anionic (-COO-) ndi magulu a hydrophilic ethylcellulose (-OH).Ma ionization a magulu -COO- amadalira pH, ndipo digiri yawo ya ionization imawonjezeka ndi pH.Choncho, HPMC ili ndi mphamvu yosungira madzi yapamwamba pa pH yapamwamba.Pa pH yotsika, gulu la -COO- limapangidwa ndi protonated ndipo hydrophilicity yake imachepa, zomwe zimapangitsa kuti madzi azikhala ochepa.Chifukwa chake, pH yachilengedwe iyenera kukonzedwa kuti ikwaniritse mphamvu yosungira madzi yomwe HPMC imafunikira.
Pomaliza
Pomaliza, mphamvu yosungira madzi ya HPMC ndichinthu chofunikira kwambiri chomwe chimakhudza magwiridwe ake ngati othandizira mankhwala.Zinthu zazikuluzikulu zomwe zimakhudza mphamvu yosungira madzi ya HPMC zimaphatikizapo kulemera kwa maselo, mtundu wolowa m'malo, ndende ndi pH mtengo.Posintha mosamala zinthu izi, mphamvu yosungira madzi ya HPMC imatha kukonzedwa kuti ikwaniritse zomwe mukufuna pazomaliza.Ofufuza ndi opanga mankhwala akuyenera kuyang'anitsitsa zinthu izi kuti awonetsetse kuti mankhwala opangidwa ndi HPMC ndi apamwamba kwambiri komanso ogwira ntchito.
Nthawi yotumiza: Aug-05-2023