Zomwe zimatha kusungunula HPMC

Hydroxypropyl methylcellulose (HPMC) ndi polima yemwe amagwiritsidwa ntchito kwambiri muzamankhwala, zodzoladzola, zakudya, ndi ntchito zina zosiyanasiyana zamafakitale.Amagwiritsidwa ntchito kwambiri chifukwa cha biocompatibility, kusakhala ndi kawopsedwe, komanso kuthekera kosintha ma rheological a mayankho.Komabe, ndikofunikira kumvetsetsa momwe mungasungunulire HPMC moyenera kuti mugwiritse ntchito bwino zinthu zake.

Madzi: HPMC imasungunuka kwambiri m'madzi, ndikupangitsa kuti ikhale chisankho chokondedwa pamapulogalamu ambiri.Komabe, kuchuluka kwa kusungunuka kumatha kusiyanasiyana kutengera zinthu monga kutentha, pH, ndi kalasi ya HPMC yogwiritsidwa ntchito.

Organic Solvents: Zosungunulira zosiyanasiyana za organic zimatha kusungunula HPMC mosiyanasiyana.Zina zodziwika bwino za organic solvents ndi:

Mowa: Isopropanol (IPA), Mowa, methanol, etc. Mowa izi nthawi zambiri ntchito formulations mankhwala ndipo akhoza bwino kupasuka HPMC.
Acetone: Acetone ndi chosungunulira champhamvu chomwe chimatha kusungunula HPMC bwino.
Ethyl Acetate: Ndizinthu zina zosungunulira zomwe zimatha kusungunula HPMC bwino.
Chloroform: Chloroform ndi chosungunulira chovuta kwambiri ndipo chiyenera kugwiritsidwa ntchito mosamala chifukwa cha kawopsedwe kake.
Dimethyl Sulfoxide (DMSO): DMSO ndi polar aprotic zosungunulira zomwe zimatha kusungunula mitundu yambiri yamagulu, kuphatikiza HPMC.
Propylene Glycol (PG): PG imagwiritsidwa ntchito nthawi zambiri ngati chosungunulira pakupanga mankhwala.Ikhoza kusungunula HPMC bwino ndipo imagwiritsidwa ntchito molumikizana ndi madzi kapena zosungunulira zina.

Glycerin: Glycerin, yomwe imadziwikanso kuti glycerol, ndi yosungunulira wamba muzamankhwala ndi zodzoladzola.Nthawi zambiri amagwiritsidwa ntchito limodzi ndi madzi kuti asungunuke HPMC.

Polyethylene Glycol (PEG): PEG ndi polima yokhala ndi kusungunuka kwabwino m'madzi ndi zosungunulira zambiri.Itha kugwiritsidwa ntchito kusungunula HPMC ndipo nthawi zambiri imagwiritsidwa ntchito popanga zotulutsa zokhazikika.

Ma Surfactants: Ma surfactants ena amatha kuthandizira kusungunuka kwa HPMC pochepetsa kupsinjika kwa pamwamba ndikuwongolera kunyowetsa.Zitsanzo zikuphatikizapo Tween 80, sodium lauryl sulfate (SLS), ndi polysorbate 80.

Ma Acid Amphamvu Kapena Maziko: Ngakhale kuti sagwiritsidwa ntchito kawirikawiri chifukwa cha chitetezo komanso kuwonongeka kwa HPMC, ma asidi amphamvu (monga hydrochloric acid) kapena maziko (monga sodium hydroxide) amatha kusungunula HPMC pamikhalidwe yoyenera.Komabe, zovuta za pH zimatha kuyambitsa kuwonongeka kwa polima.

Ma Agents Complexing: Ma cyclodextrins ena amatha kupanga ma complex ophatikizika ndi HPMC, kuthandizira kusungunuka kwake komanso kusungunuka kwake.

Kutentha: Nthawi zambiri, kutentha kwambiri kumawonjezera kusungunuka kwa HPMC mu zosungunulira monga madzi.Komabe, kutentha kwambiri kumatha kuwononga polima, chifukwa chake ndikofunikira kugwira ntchito m'malo otetezeka.

Mechanical Agitation: Kuyambitsa kapena kusakaniza kungathandize kutha kwa HPMC powonjezera kulumikizana pakati pa polima ndi zosungunulira.

Kukula kwa Particle: Finely ufa HPMC idzasungunuka mosavuta kuposa tinthu tating'onoting'ono chifukwa cha kuchuluka kwa malo.

Ndikofunikira kudziwa kuti kusankha kwa zosungunulira ndi kusungunuka kumatengera momwe chinthucho chimagwirira ntchito komanso zomwe mukufuna.Kugwirizana ndi zosakaniza zina, kulingalira za chitetezo, ndi zofunikira zoyendetsera ntchito zimakhudzanso kusankha kwa zosungunulira ndi njira zowonongeka.Kuphatikiza apo, ndikofunikira kuchititsa maphunziro ofananira ndikuyesa kukhazikika kuti muwonetsetse kuti kutha sikusokoneza mtundu kapena magwiridwe antchito a chinthu chomaliza.